Explore the role of DNA methylation in gene regulation, and how our Methylation Analysis Services can unlock new insights across diverse research domains.
DNA methylation is a key epigenetic mechanism that regulates gene expression without altering the underlying DNA sequence. Vitalytics BioScience’s Methylation Analysis Services provide a powerful tool to uncover how gene regulation changes across different conditions, including cancer, neurological disorders, and developmental abnormalities.
DNA methylation is an epigenetic mechanism that involves the addition of methyl groups to cytosine-phosphate-guanine (CpG) sites, regulating gene expression without altering the underlying DNA sequence.Ensure your histone modification data is ready for in-depth analysis with thorough quality control and normalization procedures.
Methylation can effectively turn genes on or off, influencing numerous biological processes such as X-chromosome inactivation, genomic imprinting, and the silencing of tumor suppressor genes in cancer.
Innovations in technologies like Whole Genome Bisulfite Sequencing (WGBS), single-cell methylation sequencing, and machine learning integration have made methylation analysis more precise and informative.
Methylation analysis is crucial for understanding cancer development, developmental biology, neurological disorders, personalized medicine, biomarker discovery, and integrating multi-omic data.
Identify hyper-methylated tumor suppressor genes or hypo-methylated oncogenes, which are crucial for understanding cancer development and progression.
Investigate how DNA methylation governs embryonic development and influences cell differentiation.
Explore the role of epigenetic changes in diseases such as Alzheimer’s, schizophrenia, and autism, providing new insights into their molecular basis.
Utilize methylation markers to predict drug responses and treatment outcomes, helping to tailor therapies to individual patients.
Identify epigenetic biomarkers for diagnostics and prognostics, aiding in disease detection and monitoring.
Integrate methylation data with transcriptomics and proteomics to gain a deeper understanding of regulatory mechanisms and biological pathways.
| Methylation Analysis Technique | Description |
|---|---|
|
Whole Genome Bisulfite Sequencing (WGBS) |
Perform comprehensive methylation profiling at single-base resolution, providing a complete view of the methylome. |
|
Targeted Bisulfite Sequencing |
Focused analysis of specific genomic regions, such as promoters, enhancers, or CpG islands, to investigate gene-specific methylation. |
|
Reduced Representation Bisulfite Sequencing (RRBS) |
A cost-effective approach for genome-wide methylation analysis, offering a balance between coverage and cost. |
|
Methylation Array Services |
High-throughput methylation analysis using platforms like Illumina MethylationEPIC BeadChip for targeted and reproducible insights. |
|
Data Integration and Multi-Omic Analysis |
Combine methylation data with other omics platforms to create a holistic view of gene regulation. |
|
Bioinformatics Analysis |
Advanced bioinformatics support, including methylation calling, differential methylation analysis, and pathway enrichment to extract meaningful insights from your data. |
|
Data Visualization and Reporting |
Generate high-quality visuals, such as heatmaps, methylation profiles, and interactive plots, along with a comprehensive report detailing the biological significance of your findings. |
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